Causal Relationships between Homocysteine and the Polycystic Ovary Syndrome: A Mendelian Randomization Analysis

Xianping Lin; Yaojuan Jin; Shihao Hong

doi:10.1155/2024/3090797

Causal Relationships between Homocysteine and the Polycystic Ovary Syndrome: A Mendelian Randomization Analysis

Int J Endocrinol. 2024 May 7:2024:3090797. doi: 10.1155/2024/3090797. eCollection 2024.

Authors

Xianping Lin¹, Yaojuan Jin², Shihao Hong³

Affiliations

¹ Nursing Department, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
² Hospital Department of Obstetrics and Gynecology, Linhai Second People's Hospital, Taizhou 317016, China.
³ Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou 310016, China.

Abstract

Background: Polycystic ovary syndrome (PCOS) is an endocrine disease attributed to multiple genetic variants and environmental factors. We aimed to find the causal association of homocysteine (Hcy) with PCOS.

Methods: A two-sample Mendelian randomization (MR) analysis was performed. We selected 14 single-nucleotide polymorphisms (SNPs) as instrumental variables to predict the risk of PCOS from genome-wide association studies (GWAS). The summary statistics of PCOS were obtained from 3 large genome-wide association studies in the European population, involving 4,138 cases and 20,129 controls, 3,609 cases and 229,788 controls, 994 cases and 165,817 controls, separately.

Results: The IVM analyses revealed that plasma Hcy levels were not causally associated with the risk of PCOS in the meta-analysis (combined effect = 1.032, 95% confidence interval (CI): 0.885-1.203, p=0.688).

Conclusions: There was no sufficient evidence to support the causal association of the Hcy with the risk of PCOS.