Recent Advances in the Synthesis of Diarylheptanoids

Sudarshan Kasireddy; Suresh Yarlagadda; Sagnik Sengupta

doi:10.1002/asia.202400380

Recent Advances in the Synthesis of Diarylheptanoids

Chem Asian J. 2024 May 14:e202400380. doi: 10.1002/asia.202400380. Online ahead of print.

Authors

Sudarshan Kasireddy¹, Suresh Yarlagadda¹, Sagnik Sengupta²

Affiliations

¹ Purdue University, Chemistry, 720 Clinic Drive, Institute for Drug Discovery, 47907, West Lafayette, UNITED STATES.
² Purdue University, Chemistry, 720 Clinic Drive, Institute for Drug Discvoery, 47907, West Lafayette, UNITED STATES.

PMID: 38744677
DOI: 10.1002/asia.202400380

Abstract

In the quest for synthesizing biologically important natural products, medicinal chemists embark on an endless journey. This review focuses on the reports published towards the syntheses of diarylheptanoids, classifying them into linear, tetrahydropyran, diarylether, and biphenyl categories. The synthesis methods for each class from 2013 to 2023 are discussed, providing a comprehensive overview of the advancements in the field. Representative natural product examples are highlighted for each category. The review emphasizes the importance of diarylheptanoids in the realms of chemistry and medicine, showcasing their potential as valuable compounds for medicinal and synthetic chemists.

Keywords: Acerogenin; Centrolobine; Diarylheptanoids; Macrocyclization; olefin metathesis.