Clinical, Radiological, and Pathological Correlation of Mandibular Invasion in Carcinoma Bucco-alveolar Complex

Subinsha A; Rupa Mehta; Nitin M Nagarkar; Narendra K Bodhey; Rakesh Kumar Gupta; Satish S Satpute

doi:10.1007/s13193-024-01903-3

Clinical, Radiological, and Pathological Correlation of Mandibular Invasion in Carcinoma Bucco-alveolar Complex

Indian J Surg Oncol. 2024 Jun;15(2):385-396. doi: 10.1007/s13193-024-01903-3. Epub 2024 Feb 28.

Authors

Subinsha A¹, Rupa Mehta¹, Nitin M Nagarkar¹, Narendra K Bodhey², Rakesh Kumar Gupta³, Satish S Satpute¹

Affiliations

¹ Department of Otorhinolaryngology-Head and Neck Surgery, AIIMS, Raipur, Chhattisgarh India.
² Department of Radiodiagnosis, AIIMS, Raipur, Chhattisgarh India.
³ Department of Pathology and Laboratory Medicine, AIIMS, Raipur, Chhattisgarh India.

PMID: 38741646
PMCID: PMC11088584 (available on 2025-06-01)
DOI: 10.1007/s13193-024-01903-3

Abstract

A prospective cross-sectional study was conducted to correlate clinically, radiologically, and pathologically the mandibular invasion in carcinoma bucco-alveolar complex. All biopsy-proven oral cavity cancer cases (64 patients) were assessed clinically and radiologically for involvement of the mandible. Preoperative clinicoradiological findings were compared with postoperative histopathological findings. In our study, oral cancer was 4 times more prevalent in males as compared to females and clinical evaluation was found to be highly sensitive in predicting mandibular invasion. Orthopantomogram showed sensitivity of 66.6% and specificity of 100%. CT scan showed sensitivity of 100% and specificity of 46% whereas MRI showed sensitivity of 54.5% and a specificity of 96%. MRI correlates well with final histopathology in predicting size of tumor. Prevalence of bony invasion in carcinoma oral cavity was 18%. We noted an inverse relation with tumor differentiation and mandibular invasion, and none of the verrucous carcinoma lesions showed mandibular invasion. Association of clinical T and N staging with postoperative histopathology was found to be statistically significant. Despite recent advances in molecular biology, radiological techniques, and newer modalities like visual surgical planning, exact measurement of bone invasion is still challenging. At present, CT scan and MRI along with clinical evaluation are widely used to evaluate mandibular invasion in carcinoma oral cavity, and all these are complementary to each other. The recent progress in tissue engineering technologies and stem cell biology has significantly promoted the development of regenerative reconstruction of jawbone defects.

Keywords: Clinicoradiological evaluation; Mandible erosion; Mandibular canal; Mandibulectomy; Oral cancer.

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