A Novel Gene Fusion YLPM1::PRKD1 Identified in a Cribriform Subtype of Polymorphous Adenocarcinoma

Head Neck Pathol. 2024 May 13;18(1):43. doi: 10.1007/s12105-024-01648-z.

Abstract

Cribriform adenocarcinoma of the salivary gland (CASG) is an entity that is currently classified under polymorphous adenocarcinoma (PAC), cribriform subtype per the 2022 WHO classification of head and neck tumours. There is debate about whether CASG should be considered a separate diagnostic entity, as CASG differs from conventional PAC in anatomic site, clinical behaviors, and molecular patterns. Herein we describe a challenging and unique case which shares histologic and behavioral features between CASG and conventional PAC with a YLPM1::PRKD1 rearrangement not previously reported in the literature.

Keywords: Gene fusion; Head and neck pathology; Oral pathology; Palate; Salivary gland neoplasm.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma* / genetics
  • Adenocarcinoma* / pathology
  • Female
  • Gene Fusion
  • Humans
  • Male
  • Middle Aged
  • Oncogene Proteins, Fusion / genetics
  • Protein Kinase C
  • Salivary Gland Neoplasms / genetics
  • Salivary Gland Neoplasms / pathology

Substances

  • protein kinase D
  • Oncogene Proteins, Fusion
  • Protein Kinase C