Primary mucinous tumors of the renal pelvis: Clinical, histopathological, and molecular analysis of three cases

Huifang Zhang; Weiqiang Wu; Shanshan Wu; Xiaodong Teng

doi:10.1016/j.anndiagpath.2024.152325

Primary mucinous tumors of the renal pelvis: Clinical, histopathological, and molecular analysis of three cases

Ann Diagn Pathol. 2024 May 8:72:152325. doi: 10.1016/j.anndiagpath.2024.152325. Online ahead of print.

Authors

Huifang Zhang¹, Weiqiang Wu¹, Shanshan Wu², Xiaodong Teng³

Affiliations

¹ Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310000 Hangzhou, Zhejiang Province, China.
² Department of Pathology, Taizhou Hospital of Zhejiang Province affliated to Wenzhou Medical University, 318000 Taizhou, Zhejiang Province, China.
³ Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310000 Hangzhou, Zhejiang Province, China. Electronic address: teng1102069@zju.edu.cn.

PMID: 38733673
DOI: 10.1016/j.anndiagpath.2024.152325

Abstract

Primary mucinous tumors of the renal pelvis are extremely rare and pose challenges in terms of diagnosis and treatment. This study reviewed the clinical and pathological characteristics of mucinous tumors of the renal pelvis, including mucinous cystadenocarcinomas and mucinous cystadenomas. Immunohistochemical analysis was conducted in three cases, along with KRAS gene detection using the Amplification Refractory Mutation System (ARMS) method. The results revealed mucinous epithelium with acellular mucinous pools in all cases, and acellular mucinous pools were observed in the renal parenchyma and perirenal fat capsules. All tumors expressed CK20 and CDX2, and one case showed KRAS gene mutation. The study suggests that mucinous cystadenomas of the renal pelvis may exhibit borderline biological behaviors. This study is the first to report a KRAS gene mutation in a mucinous cystadenoma of the renal pelvis, offering valuable insights into the diagnosis and treatment of this rare condition.

Keywords: KRAS; Mucinous cystadenocarcinoma; Mucinous cystadenoma; Mucinous tumors; Renal pelvis.