Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity

Ranran Zhang; Zhen Lu; Derui Wang; Zhi Yan; Xueting Sun; Xiaodong Li; Xiuli Yin; Ke Li

doi:10.1080/14786419.2024.2350639

Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity

Nat Prod Res. 2024 May 11:1-7. doi: 10.1080/14786419.2024.2350639. Online ahead of print.

Authors

Ranran Zhang^{1

2}, Zhen Lu¹, Derui Wang^{1

3}, Zhi Yan^{1

4}, Xueting Sun¹, Xiaodong Li¹, Xiuli Yin¹, Ke Li¹

Affiliations

¹ Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China.
² College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, China.
³ College of Marine sciences, Beibu Gulf University, Qinzhou, China.
⁴ School of Ocean, Yantai University, Yantai, China.

PMID: 38733627
DOI: 10.1080/14786419.2024.2350639

Abstract

Many marine organisms possess an essential capacity to produce secondary metabolites that exhibit toxic characteristics. A new polyhydroxy steroid, 24-methyl-5α-cholestane-24(28)-ene-3β, 4β, 6α, 7α, 8, 15β, 16β, 26-octol-6-O-sodium sulphate (1) was isolated from starfish (Asterina pectinifera), along with five polar steroid compounds (2-6) that were previously identified. NMR (¹H and ¹³C NMR, ¹H-¹H COSY, HSQC, HMBC, and NOESY) and HR-ESI-MS were employed for structure elucidations. The embryotoxicity and teratogenicity of the isolated compounds were assessed using embryos of marine medaka (Oryzias melastigma). Compound 5 exhibited moderate embryotoxicity (96h-LC₅₀: 65 μM).

Keywords: Asterina pectinifera; Polyhydroxy steroids; embryotoxicity; starfish.