[Challenges and optimization strategies for clinical research and the development of new drugs for liver fibrosis]

Zhonghua Gan Zang Bing Za Zhi. 2024 Apr 20;32(4):303-305. doi: 10.3760/cma.j.cn501113-20240226-00095.
[Article in Chinese]

Abstract

Liver fibrosis is a key step in the developmental process of various chronic liver diseases, including cirrhosis. Therefore, the focus and difficulty of liver disease research have always been on how to reverse liver fibrosis. However, due to complex mechanisms, difficulties in endpoint evaluation, a lack of non-invasive diagnostic methods, and other factors, the research and development of new drugs are hindered and lengthy. Currently, some new drugs are being researched and developed, which signifies the prospect is optimistic.

肝纤维化是各种慢性肝病向肝硬化发展过程中的关键步骤,如何能通过药物逆转肝纤维化始终为肝病领域研究的重点和难点。然而,由于机制复杂、终点评估困难、缺少无创诊断方法等因素,一些新的药物正在研发中,肝纤维化新药研发道阻且长,但前景乐观。.

Keywords: Liver fibrosis; New drugs; Research and development.

Publication types

  • English Abstract

MeSH terms

  • Drug Development
  • Humans
  • Liver Cirrhosis* / drug therapy