Abietane Diterpenoids from the Bark of Cryptomeria japonica and Their Antifungal Activities against Wood Decay Fungi

Chi-I Chang; Cheng-Chi Chen; Sheng-Yang Wang; Yueh-Hsiung Kuo

doi:10.3390/plants13091197

Abietane Diterpenoids from the Bark of Cryptomeria japonica and Their Antifungal Activities against Wood Decay Fungi

Plants (Basel). 2024 Apr 25;13(9):1197. doi: 10.3390/plants13091197.

Authors

Chi-I Chang^{1

2}, Cheng-Chi Chen³, Sheng-Yang Wang^{4

5}, Yueh-Hsiung Kuo^{6

7

8}

Affiliations

¹ Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan.
² Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan.
³ Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
⁴ Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan.
⁵ Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan.
⁶ Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan.
⁷ Department of Biotechnology, Asia University, Taichung 413, Taiwan.
⁸ Chinese Medicine Research Center, China Medical University, Taichung 404, Taiwan.

Abstract

Phytochemical investigation of the bark of Cryptomeria japonica led to the isolation of five new abietane diterpenoids, 5-epi-12-hydroxy-6-nor-5,6-secoabieta-8,11,13-trien-7,5-olide (1), 12-hydroxy-6β-methoxy-6,7-secoabieta-8,11,13-trien-7,6-olide (2), 6β,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (4), 5,12-dihydroxy-7,8-secoabieta-8,11,13-trien-7,8-olide (5), and 5α,8-epoxy-12-hydroxy-7,8-secoabieta-8,11,13-trien-7-al (6), together with one known abietane diterpenoid, obtuanhydride (3). Their structures were elucidated by analysis of spectroscopic data and comparison with the spectral data of known analogs. At the concentration of 100 μg/mL, compounds 4, 5, and 6 inhibited antifungal activities against wood decay fungi activity by 18.7, 37.2, and 46.7%, respectively.

Keywords: Cryptomeria japonica; Cupressaceae; abietane; antifungal; bark.

Abstract

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