Interplay between Drug-Induced Liver Injury and Gut Microbiota: A Comprehensive Overview

Guolin Li; Yifu Hou; Changji Zhang; Xiaoshi Zhou; Furong Bao; Yong Yang; Lu Chen; Dongke Yu

doi:10.1016/j.jcmgh.2024.05.003

Interplay between Drug-Induced Liver Injury and Gut Microbiota: A Comprehensive Overview

Cell Mol Gastroenterol Hepatol. 2024 May 8:S2352-345X(24)00109-7. doi: 10.1016/j.jcmgh.2024.05.003. Online ahead of print.

Authors

Guolin Li¹, Yifu Hou², Changji Zhang¹, Xiaoshi Zhou³, Furong Bao⁴, Yong Yang⁵, Lu Chen⁶, Dongke Yu⁷

Affiliations

¹ School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China, 211198; Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 610072.
² Department of Organ Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 610072; Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province & Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, 610072.
³ Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 610072.
⁴ Guanghan People's Hospital, Guanghan, China, 618300.
⁵ Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 610072; Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 610072. Electronic address: yyxpower@126.com.
⁶ Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 610072; Guanghan People's Hospital, Guanghan, China, 618300. Electronic address: llilychen2006@163.com.
⁷ Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 610072; Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 610072. Electronic address: kkygrace24@163.com.

PMID: 38729523
DOI: 10.1016/j.jcmgh.2024.05.003

Abstract

Drug-induced liver injury is a prevalent severe adverse event in clinical settings, leading to increased medical burdens for patients and presenting challenges for the development and commercialization of novel pharmaceuticals. Research has revealed a close association between gut microbiota and drug-induced liver injury in recent years. However, there has yet to be a consensus on the specific mechanism by which gut microbiota is involved in drug-induced liver injury. Gut microbiota may contribute to drug-induced liver injury by increasing intestinal permeability, disrupting intestinal metabolite homeostasis, and promoting inflammation and oxidative stress. Alterations in gut microbiota were found in drug-induced liver injury caused by antibiotics, psychotropic drugs, acetaminophen, anti-tuberculosis drugs, and anti-thyroid drugs. Specific gut microbiota and their abundance are closely associated with the severity of drug-induced liver injury. Therefore, gut microbiota is expected to be a new target for the treatment of drug-induced liver injury. In this review, we focus on the association of gut microbiota with common hepatotoxic drugs and the potential mechanisms by which gut microbiota may contribute to the pathogenesis of drug-induced liver injury, providing a more comprehensive reference for the interaction between drug-induced liver injury and gut microbiota.

Keywords: Drug-induced liver injury; Gut microbiota; Hepatotoxic drug,Mechanisms.

Publication types

Review