Association between breakfast skipping and blood levels of lead and cadmium in children and adolescents aged 6-17 years: Results from the national health and nutrition examination survey 2013-2018

Sonia Collado-López; Kaelyn F Burns; Samantha N Smith; Katarzyna Kordas; Gauri Desai

doi:10.1016/j.jtemb.2024.127468

Association between breakfast skipping and blood levels of lead and cadmium in children and adolescents aged 6-17 years: Results from the national health and nutrition examination survey 2013-2018

J Trace Elem Med Biol. 2024 May 4:84:127468. doi: 10.1016/j.jtemb.2024.127468. Online ahead of print.

Authors

Sonia Collado-López¹, Kaelyn F Burns², Samantha N Smith³, Katarzyna Kordas³, Gauri Desai³

Affiliations

¹ Center for Nutrition and Health Research, Instituto Nacional de Salud Pública, Cuernavaca, Morelos 62100, Mexico.
² Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY 14214, USA. Electronic address: kfburns@buffalo.edu.
³ Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY 14214, USA.

PMID: 38728997
DOI: 10.1016/j.jtemb.2024.127468

Abstract

Introduction: Previous research suggests that fasting increases lead absorption in the gastrointestinal tract, and that regularly eating meals may reduce blood lead. However, there is insufficient evidence linking breakfast status and blood-metal levels in children. We assessed the cross-sectional association between breakfast consumption status and children and adolescent's blood levels of lead and cadmium. We also explored blood hemoglobin, serum ferritin, and age group as potential effect modifiers of these associations.

Methods: This analysis included children and adolescents aged 6-17 years who participated in the National Health and Nutrition Examination Survey (NHANES) cycles 2013-2018 with complete data on breakfast consumption status (consumers vs. skippers), blood metals, and covariates (N=3722). Blood metal variables were log-transformed. Crude and covariate-adjusted, survey-weighted linear regression models were conducted for each blood metal outcome. Potential effect modification was explored using stratification.

Results: Overall fewer participants reported skipping breakfast (n=719) than eating breakfast (n=3003). Mean (SE) concentrations of blood lead and cadmium (µg/L) were 0.63 (0.01) µg/dL and 0.13 (0.00) µg/L, respectively. Children and adolescents who skipped breakfast were more likely to be female (51.2%), older (mean 12.2 years, SE = 0.1), have a higher body mass index (mean 22.8 kg/m², SE = 0.2), and a lower income-poverty ratio (mean 1.7, SE = 0.1) than breakfast consumers. No associations between breakfast consumption and any of the blood metals were found. When stratified by age (≤ 10, 11-13, and 14-17 years), children aged 11-13 years who consumed breakfast had lower log-transformed blood lead levels [β = -0.14 µg/L; 95% CI: (-0.25, -0.03)] compared to children of the same age who skipped breakfast.

Conclusion: Children 11-13 years-old who were breakfast consumers had lower blood lead levels compared to children of the same age who skipped breakfast. Our results support that encouraging breakfast consumption among school-age children may contribute to lower blood lead levels.

Keywords: Blood cadmium; Blood lead; Blood metals; Breakfast consumption; Children; NHANES.