This paper shows for the first time that co-transplantation of human olfactory ensheathing cells with neurotrophin-3 into spinal cord cysts is more effective for activation of remyelination than transplantation of cells with brain-derived neurotrophic factor and a combination of these two factors. The studied neurotrophic factors do not affect proliferation and migration of ensheathing cells in vitro. It can be concluded that the maximum improvement of motor function in rats receiving ensheathing cells with neurotrophin-3 is largely determined by activation of remyelination.
Keywords: brain-derived neurotrophic factor (BDNF); neurotrophin-3 (NT-3); olfactory ensheathing cells; remyelination; spinal cord cysts.
© 2024. Springer Science+Business Media, LLC, part of Springer Nature.