Factors associated with discrepancies in disease activity as assessed by SDAI and RAPID3 in patients with rheumatoid arthritis: Data from a multicenter observational study (T-FLAG)

Mochihito Suzuki; Shuji Asai; Yoshifumi Ohashi; Yasumori Sobue; Hisato Ishikawa; Nobunori Takahashi; Kenya Terabe; Ryo Sato; Hironobu Kosugiyama; Junya Hasegawa; Yusuke Ohno; Takaya Sugiura; Shiro Imagama

doi:10.1093/mr/roae040

Factors associated with discrepancies in disease activity as assessed by SDAI and RAPID3 in patients with rheumatoid arthritis: Data from a multicenter observational study (T-FLAG)

Mod Rheumatol. 2024 May 10:roae040. doi: 10.1093/mr/roae040. Online ahead of print.

Authors

Mochihito Suzuki^{1

2}, Shuji Asai¹, Yoshifumi Ohashi^{1

3

4}, Yasumori Sobue⁵, Hisato Ishikawa⁵, Nobunori Takahashi⁴, Kenya Terabe¹, Ryo Sato¹, Hironobu Kosugiyama¹, Junya Hasegawa¹, Yusuke Ohno¹, Takaya Sugiura¹, Shiro Imagama¹

Affiliations

¹ Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Aichi, Japan.
² Department of Orthopedic Surgery, Japan Community Health care Organization Kani Tono Hospital, Gifu, Japan.
³ Department of Orthopedic Surgery, Yokkaichi Municipal Hospital, Mie, Japan.
⁴ Department of Orthopedic Surgery, Aichi Medical University, Aichi, Japan.
⁵ Department of Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Aichi, Japan.

PMID: 38727542
DOI: 10.1093/mr/roae040

Abstract

Objectives: The present study aimed to examine discrepancies between assessments based on Routine Assessment of Patient Index Data 3 (RAPID3) and Simple Disease Activity Index (SDAI) in RA patients with controlled disease activity.

Methods: Data from 464 RA patients in SDAI remission or low disease activity (REM/LDA) were analyzed. Patient-reported outcome (PRO) measures, including Health Assessment Questionnaire Disability Index (HAQ-DI), 25-question Geriatric Locomotive Function Scale (GLFS-25), and Kihon checklist (KCL), were assessed. Logistic regression models were used to identify factors associated with RAPID3 moderate or high disease activity (MDA/HDA). Cutoff values of RAPID3 MDA/HDA for each PRO evaluation item were determined using receiver operating characteristic curve analysis.

Results: Among RA patients in SDAI REM/LDA, 84.9% were in RAPID3 REM/LDA. Multivariable analysis revealed that HAQ-DI, GLFS-25, and KCL were independently associated with RAPID3 MDA/HDA. Subdomain analysis of KCL revealed that activities of daily living, physical function, cognitive function, and depressive mood were significantly associated with RAPID3 MDA/HDA. Cutoff values for HAQ-DI and KCL were 0.38 and 8, respectively.

Conclusions: In RA patients with controlled disease activity, discrepancies between RAPID3 and SDAI assessments were observed, with factors such as HAQ-DI, GLFS-25, and KCL being independently associated with RAPID3 MDA/HDA.

Keywords: Discrepancy; Frailty; Patient Reported Outcome; Rheumatoid Arthritis; Routine Assessment of Patient Index Data 3.

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