Preoperative COVID-19 Vaccination is Associated with Decreased Perioperative Mortality after Major Vascular Surgery

Molly Ratner; Karan Garg; Heepeel Chang; Anjali Nigalaye; Steven Medvedovsky; Glenn Jacobowitz; Jeffrey J Siracuse; Virendra Patel; Marc Schermerhorn; Charles DiMaggio; Caron B Rockman

doi:10.1097/SLA.0000000000006341

Preoperative COVID-19 Vaccination is Associated with Decreased Perioperative Mortality after Major Vascular Surgery

Ann Surg. 2024 May 10. doi: 10.1097/SLA.0000000000006341. Online ahead of print.

Affiliations

¹ Division of Vascular and Endovascular Surgery, Department of Surgery, New York University Langone Medical Center, New York, NY.
² Division of Vascular Surgery, Department of Surgery, Westchester Medical Center, Valhalla, NY.
³ Division of Hospitalist Medicine, Department of Medicine, Mount Sinai Beth Israel Hospital, New York, NY.
⁴ Division of Vascular and Endovascular Surgery, Department of Surgery, Boston Medical Center, Boston, Massachusetts.
⁵ Division of Vascular and Endovascular Interventions, Department of Surgery, New York Presbyterian- Columbia University Irving Medical Center, New York, NY.
⁶ Division of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

PMID: 38726660
DOI: 10.1097/SLA.0000000000006341

Abstract

Objective: The objective of this study was to examine the effect of corona virus 2019 (COVID-19) vaccination on perioperative outcomes after major vascular surgery.

Background data: COVID-19 vaccination is associated with decreased mortality in patients undergoing various surgical procedures. However, the effect of vaccination on perioperative mortality after major vascular surgery is unknown.

Methods: This is a multicenter retrospective study of patients who underwent major vascular surgery between December 2021 through August 2023. The primary outcome was all-cause mortality within 30 days of index operation or prior to hospital discharge. Multivariable models were used to examine the association between vaccination status and the primary outcome.

Results: Of the total 85,424 patients included, 19161 (22.4%) were unvaccinated. Unvaccinated patients were younger compared to vaccinated patients (mean age 68.44 +/- 10.37 y vs 72.11 +/- 9.20 y, P <0.001) and less likely to have comorbid conditions, including hypertension, congestive heart failure, chronic obstructive pulmonary disease, and dialysis. After risk factor adjustment, vaccination was associated with decreased mortality (OR 0.7, 95% CI 0.62 - 0.81, P <0.0001). Stratification by procedure type demonstrated that vaccinated patients had decreased odds of mortality after open AAA (OR 0.6, 95% CI 0.42-0.97, P =0.03), EVAR (OR 0.6, 95% CI 0.43-0.83, p 0.002), CAS (OR 0.7, 95% CI 0.51-0.88, P =0.004) and infra-inguinal lower extremity bypass (OR 0.7, 95% CI 0.48-0.96, P =0.03).

Conclusions: COVID-19 vaccination is associated with reduced perioperative mortality in patients undergoing vascular surgery. This association is most pronounced for patients undergoing aortic aneurysm repair, carotid stenting and infrainguinal bypass.