The impact of flaxseed oil on lipid profiles, weight loss, and inflammatory markers in hemodialysis patients: A systematic review and meta-analysis of randomized controlled trials

Reza Tabrizi; Zahra Azizi; Sina Bazmi; Omid Keshavarzian; Maryam Akbari; Zeinab Karimimoghadam; Abdolreza Haghpanah

doi:10.1111/1744-9987.14140

The impact of flaxseed oil on lipid profiles, weight loss, and inflammatory markers in hemodialysis patients: A systematic review and meta-analysis of randomized controlled trials

Ther Apher Dial. 2024 May 10. doi: 10.1111/1744-9987.14140. Online ahead of print.

Authors

Reza Tabrizi^{1

2}, Zahra Azizi³, Sina Bazmi⁴, Omid Keshavarzian⁵, Maryam Akbari⁶, Zeinab Karimimoghadam¹, Abdolreza Haghpanah⁷

Affiliations

¹ Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
² Clinical Research Development Unit, Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Iran.
³ Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
⁴ USERN Office, Fasa University of Medical Sciences, Fasa, Iran.
⁵ School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
⁶ Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
⁷ Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

PMID: 38726572
DOI: 10.1111/1744-9987.14140

Abstract

Studies investigating the effects of flaxseed oil on lipid profiles, weight loss, and inflammatory markers have produced inconsistent results. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to explore the impact of flaxseed oil on these parameters in hemodialysis patients. The study protocol was registered online (PROSPERO number: CRD42023484076). The meta-analyses showed a significant decrease in triglyceride (TG) levels (WMD = -85.78 mg/dL, 95% CI: -155.24 to -16.32, I² = 98.32%) and C-reactive protein (CRP) levels (WMD = -2.66 mg/L, 95% CI: -4.07 to -1.24, I² = 92.26%) following consumption of flaxseed oil. Subgroup analyses revealed significant changes in LDL-C, HDL-C, and TC levels only in trials utilizing a dosage higher than 10 g per day and using ground flaxseed oil. Based on the results, flaxseed oil improves CRP and TG levels, and higher doses positively affect lipid profiles. However, it has no significant effect on anthropometric measures.

Keywords: flaxseed oil; hemodialysis; inflammatory markers; lipid profiles; meta‐analysis; weight loss.

Publication types

Review