The use of fixed study main effects in arm-based network meta-analysis

Res Synth Methods. 2024 May 9. doi: 10.1002/jrsm.1721. Online ahead of print.

Abstract

Methods of network meta-analysis (NMA) can be classified as arm-based and contrast-based approaches. There are several arm-based approaches, and some of these have been criticized because they recover inter-study information and hence do not obey the principle of concurrent control. Here, we point out that recovery of inter-study information in arm-based NMA can be prevented by fitting a fixed main effect for studies. Advantages of arm-based NMA are discussed.

Keywords: incomplete block design; inter‐block information; inter‐study information; recovery of information; residual maximum likelihood.