One size might fit all: Indole-3-propionic acid potentiates pan-cancer immunotherapy

Zheshun Pi; Weici Liu; Wenjun Mao

doi:10.1016/j.chom.2024.03.011

One size might fit all: Indole-3-propionic acid potentiates pan-cancer immunotherapy

Cell Host Microbe. 2024 May 8;32(5):627-630. doi: 10.1016/j.chom.2024.03.011.

Authors

Zheshun Pi¹, Weici Liu², Wenjun Mao³

Affiliations

¹ Department of Microbiota Medicine & Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China; Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China; Wuxi College of Clinical Medicine, Nanjing Medical University, Wuxi 214023, China.
² Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China; Wuxi College of Clinical Medicine, Nanjing Medical University, Wuxi 214023, China.
³ Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China; Wuxi College of Clinical Medicine, Nanjing Medical University, Wuxi 214023, China. Electronic address: maowenjun1@njmu.edu.cn.

PMID: 38723599
DOI: 10.1016/j.chom.2024.03.011

Abstract

Microbial-based therapies have the potential to combat immunotherapy resistance, extending the boundaries of oncological therapeutics. In a recent issue of Cell, Jia et al. demonstrates an example of microbial collaboration to produce a postbiotic that promotes the stemness program of CD8⁺ T cells to augment immunotherapy at the pan-cancer level.

MeSH terms

Animals
CD8-Positive T-Lymphocytes* / immunology
Humans
Immunotherapy* / methods
Indoles
Mice
Neoplasms* / drug therapy
Neoplasms* / immunology
Neoplasms* / therapy

Substances

Indoles