Altered Cortical Activity during a Finger Tap in People with Stroke

Priya Balasubramanian; Roxanne P De Leon; Dylan B Snyder; Scott A Beardsley; Allison S Hyngstrom; Brian D Schmit

doi:10.1007/s10548-024-01049-z

Altered Cortical Activity during a Finger Tap in People with Stroke

Brain Topogr. 2024 May 9. doi: 10.1007/s10548-024-01049-z. Online ahead of print.

Authors

Priya Balasubramanian¹, Roxanne P De Leon¹, Dylan B Snyder¹, Scott A Beardsley¹, Allison S Hyngstrom², Brian D Schmit³

Affiliations

¹ Department of Biomedical Engineering, Marquette University, P.O. Box 1881, Milwaukee, WI, 53201, USA.
² Department of Physical Therapy, Marquette University, Milwaukee, WI, 53201, USA.
³ Department of Biomedical Engineering, Marquette University, P.O. Box 1881, Milwaukee, WI, 53201, USA. brian.schmit@marquette.edu.

PMID: 38722465
DOI: 10.1007/s10548-024-01049-z

Abstract

This study describes electroencephalography (EEG) measurements during a simple finger movement in people with stroke to understand how temporal patterns of cortical activation and network connectivity align with prolonged muscle contraction at the end of a task. We investigated changes in the EEG temporal patterns in the beta band (13-26 Hz) of people with chronic stroke (N = 10, 7 F/3 M) and controls (N = 10, 7 F/3 M), during and after a cued movement of the index finger. We quantified the change in beta band EEG power relative to baseline as activation at each electrode and the change in task-based phase-locking value (tbPLV) and beta band task-based coherence (tbCoh) relative to baseline coherence as connectivity between EEG electrodes. Finger movements were associated with a decrease in beta power (event related desynchronization (ERD)) followed by an increase in beta power (event related resynchronization (ERS)). The ERS in the post task period was lower in the stroke group (7%), compared to controls (44%) (p < 0.001) and the transition from ERD to ERS was delayed in the stroke group (1.43 s) compared to controls (0.90 s) in the C3 electrode (p = 0.007). In the same post movement period, the stroke group maintained a heightened tbPLV (p = 0.030 for time to baseline of the C3:Fz electrode pair) and did not show the decrease in connectivity in electrode pair C3:Fz that was observed in controls (tbPLV: p = 0.006; tbCoh: p = 0.023). Our results suggest that delays in cortical deactivation patterns following movement coupled with changes in the time course of connectivity between the sensorimotor and frontal cortices in the stroke group might explain clinical observations of prolonged muscle activation in people with stroke. This prolonged activation might be attributed to the combination of cortical reorganization and changes to sensory feedback post-stroke.

Keywords: Beta band; Connectivity; Cortical activation; EEG; Event-related desynchronization; Event-related synchronization.