Associations between antiretroviral regimen and changes in blood pressure: results from the D2EFT study

Phyo Pyae Nyein; Kathy Petoumenos; Margaret Borok; Nnakelu Eriobu; Nagalingeswaran Kumarasamy; Anchalee Avihingsanon; Iskandar Azwa; Sounkalo Dao; Mohamed Cisse; Nila J Dharan; Josh Hanson; Gail V Matthews

doi:10.1093/cid/ciae256

Associations between antiretroviral regimen and changes in blood pressure: results from the D2EFT study

Clin Infect Dis. 2024 May 9:ciae256. doi: 10.1093/cid/ciae256. Online ahead of print.

Affiliations

¹ The Kirby Institute, University of New South Wales, Australia.
² University of Zimbabwe Clinical Research Centre, Zimbabwe.
³ Institue of Human Virology Nigeria, Nigeria.
⁴ Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS) Voluntary Health Services (VHS), India.
⁵ The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Thai Red Cross AIDS Research Centre, Thailand.
⁶ University of Malaya Medical Centre (UMMC), Malaysia.
⁷ University Clinical Research Centre (UCRC), Mali.
⁸ Centre de traitement ambulatoire de Donka (Hospital de jour), Guinea.

PMID: 38721980
DOI: 10.1093/cid/ciae256

Abstract

In this randomised, controlled study in 14 low- and middle-income countries, individuals taking dolutegravir with darunavir/ritonavir for 48 weeks had a greater increase in systolic and diastolic blood pressure than individuals taking two nucleoside reverse transcriptase with darunavir/ritonavir. The difference remained significant after controlling for confounding factors including weight gain.

Keywords: HIV; cardiovascular risk; dolutegravir; hypertension; low- and middle-income countries.

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