Risk factors for healthcare-associated candidemia in adults hospitalized with SARS-CoV-2 infection

Zachary M Most; John J Hanna; Alexander P Radunsky; Lauren N Cooper; Christoph U Lehmann; Trish M Perl; Richard J Medford

doi:10.1017/ash.2024.25

Risk factors for healthcare-associated candidemia in adults hospitalized with SARS-CoV-2 infection

Antimicrob Steward Healthc Epidemiol. 2024 May 2;4(1):e69. doi: 10.1017/ash.2024.25. eCollection 2024.

Authors

Zachary M Most¹, John J Hanna^{2

3

4

5}, Alexander P Radunsky², Lauren N Cooper³, Christoph U Lehmann^{3

6

7}, Trish M Perl^{2

6}, Richard J Medford^{2

3

4

5}

Affiliations

¹ Division of Infectious Disease, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
² Division of Infectious Disease and Geographic Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
³ Clinical Informatics Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
⁴ Division of Infectious Diseases, Department of Internal Medicine, Brody School of Medicine, Greenville, NC, USA.
⁵ Information Services, ECU Health, Greenville, NC, USA.
⁶ Peter O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
⁷ Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Abstract

Analyzing data from a national deidentified electronic health record-based data set using a matched case-control study design, we found that antibiotic use and severity of illness were independent risk factors for healthcare-associated candidemia in adult patients hospitalized with SARS-CoV-2 infection. Interleukin-6 inhibitor and corticosteroid use were not independent risk factors.