Microcosting analysis of haematopoietic stem cell transplantation and chemotherapy with intermediate doses of cytarabine in the treatment of acute myeloid leukaemia

Sitânia Chiesa; Eduardo Magalhães Rego; Vanessa Teich; Maria Isabel Ayrosa Madeira; Lorena Lobo de Figueiredo Pontes; Fabiola Traina; Leticia Olops Marani

doi:10.1016/j.htct.2024.02.028

Microcosting analysis of haematopoietic stem cell transplantation and chemotherapy with intermediate doses of cytarabine in the treatment of acute myeloid leukaemia

Hematol Transfus Cell Ther. 2024 Apr 17:S2531-1379(24)00075-0. doi: 10.1016/j.htct.2024.02.028. Online ahead of print.

Authors

Sitânia Chiesa¹, Eduardo Magalhães Rego², Vanessa Teich¹, Maria Isabel Ayrosa Madeira¹, Lorena Lobo de Figueiredo Pontes¹, Fabiola Traina¹, Leticia Olops Marani¹

Affiliations

¹ Instituto do Câncer do Estado de São Paulo da Universidade de São Paulo (Icesp - USP), São Paulo, SP, Brazil.
² Instituto do Câncer do Estado de São Paulo da Universidade de São Paulo (Icesp - USP), São Paulo, SP, Brazil. Electronic address: emrego@hcrp.fmrp.usp.br.

PMID: 38719723
DOI: 10.1016/j.htct.2024.02.028

Abstract

Background: Acute myeloid leukaemia (AML) is considered a costly disease. Depending on the risk stratification, the patient may receive consolidation with cycles of intermediate doses of cytarabine, auto-HSCT or allo-HSCT according to availability in each service and the availability of a compatible donor. Literature data indicate that safety and effectiveness do not differ between consolidation therapy with intermediate-dose cytarabine or auto-HSCT, and so the cost can help physicians and health managers in their choice.

Method: The cost of the second consolidation was compared in 18 to 60-year-old patients with de novo AML who were included in the International Consortium of Acute Myeloid Leukaemia (ICAML) protocol. Patients treated with auto-HSCT or intermediate doses of cytarabine (IDAC) were analysed during four years using the microcosting methodology.

Results: The mean costs for auto-HSCT and IDAC were BRL$ 34,900.95 (range: 23,611.36-41,229.59) and 15,231.64 (range: 6,546.36-23,253.53), respectively. The mean duration of in-hospital stay was 88.4 (93-133) and 94 (50-153) days, respectively. The mean cost of the four cycles of treatment was BRL$ 114.212,78 for auto-HSCT and BRL$ 121.980,93 for the chemotherapy group. Regardless of the type of treatment, the input that had the greatest economic impact was hospital admission, mainly due to infections.

Conclusion: Auto-HSCT had a lower average cost per patient and hospitalization rate than chemotherapy.

Keywords: Acute myeloid leukaemia; Autologous haematopoietic stem cell transplantation; Chemotherapy; Consolidation; Cost Analysis.