Three novel dihydrochalcones from Flemingia lineata (L.) W.T. Aiton and their antiplasmodial activity

Ratih Dewi Saputri; First Ambar Wati; Amalia Putri Purnamasari; Hilkatul Ilmi; Tjitjik Srie Tjahjandarie; Shola Mardhiyyah; Mulyadi Tanjung

doi:10.1080/14786419.2024.2349246

Three novel dihydrochalcones from Flemingia lineata (L.) W.T. Aiton and their antiplasmodial activity

Nat Prod Res. 2024 May 8:1-8. doi: 10.1080/14786419.2024.2349246. Online ahead of print.

Authors

Ratih Dewi Saputri¹, First Ambar Wati¹, Amalia Putri Purnamasari¹, Hilkatul Ilmi², Tjitjik Srie Tjahjandarie³, Shola Mardhiyyah², Mulyadi Tanjung^{2

3}

Affiliations

¹ Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, Indonesia.
² Center of Natural Products Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.
³ Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.

PMID: 38717217
DOI: 10.1080/14786419.2024.2349246

Abstract

Three novel dihydrochalcones, flemilineatins C-E (1-3), and two known flavanones (4-5) were isolated from Flemingia lineata (L.) W.T. Aiton leaves. Dihydrochalcones 1-3 structures were established using NMR spectrum and high-resolution ESIMS data. Compounds 1-5 were assayed to Plasmodium falciparum lactate dehydrogenase (PfLDH) for their antiplasmodial activity. Compounds 2 and 5 exhibited high activity with an IC₅₀ value of 0.74 and 0.79 µg/mL, respectively.

Keywords: Fabaceae; Flemingia lineata; antiplasmodial; dihydrochalcone; flemilineatins C–E.