Endothelial-specific Enhancer as a Cis Element of PLAUR Regulation by TNF-alpha, IL-1beta, and VEGF

Dmitry Penkov; Irina Beloglazova; Yelena Parfyonova

doi:10.2174/0113816128296376240424072322

Endothelial-specific Enhancer as a Cis Element of PLAUR Regulation by TNF-alpha, IL-1beta, and VEGF

Curr Pharm Des. 2024 May 7. doi: 10.2174/0113816128296376240424072322. Online ahead of print.

Authors

Dmitry Penkov¹, Irina Beloglazova¹, Yelena Parfyonova¹

Affiliation

¹ Laboratory of Angiogenesis, Institute of Experimental Cardiology Named after Academician V.N. Smirnov, Federal State Budgetary Institution National Medical Research Center of Cardiology Named after Academician E.I. Chazov, Ministry of Health of the Russian Federation, Moscow, Russia.

PMID: 38715331
DOI: 10.2174/0113816128296376240424072322

Abstract

The expression of human PLAUR gene, which encodes the urokinase plasminogen activator receptor (uPAR), is cell- and process-specific, elevating inflammation, cancer and senescence. Its tight regulation is achieved by regulatory elements in the gene locus, such as the promoter and several enhancers. The promoter activity is not specific to a particular cell type and has been described earlier. The proximal enhancer is endothelial- specific and responsible for the PLAUR expression pattern in endothelial cells. In this study, we described the enhancer activity and its cis elements based on the published data. We showed a possible connection of the enhancer activity with known cellular phenotypes.

Keywords: IL-1beta; PLAUR; TNF-alpha; VEGF; enhancer; promoter.; uPAR.