Natural products with potential hypoglycemic activity in T2DM: 2019-2023

Zhang Fei; Yang Xu; Guoyu Zhang; Yang Liu; Hua Li; Lixia Chen

doi:10.1016/j.phytochem.2024.114130

Natural products with potential hypoglycemic activity in T2DM: 2019-2023

Phytochemistry. 2024 May 5:223:114130. doi: 10.1016/j.phytochem.2024.114130. Online ahead of print.

Authors

Zhang Fei¹, Yang Xu¹, Guoyu Zhang¹, Yang Liu¹, Hua Li², Lixia Chen³

Affiliations

¹ Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
² Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China; Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China. Electronic address: lihua@fjtcm.edu.cn.
³ Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: syzyclx@163.com.

PMID: 38714289
DOI: 10.1016/j.phytochem.2024.114130

Abstract

As currently the most common metabolic disease, type 2 diabetes mellitus (T2DM) has shown a continuous increase in the number of patients in recent decades. Most anti-T2DM drugs tend to cause some side effects. Given the pathogenesis of T2DM, natural products have emerged as an important source of anti-T2DM drugs. This article reviews natural products with potential hypoglycemic activity from 2019 to 2023. A total of 200 previously natural products were discovered on SciFinder, PubMed and Web of Science. These products were categorized based on their structural frameworks and their biological activities were summarized. Although the mechanisms of action of most compounds are unclear, these compounds could still serve as candidates for the development of lead compounds. Therefore, further structure and activity research of natural products will significantly contribute to the development of potential anti-T2DM drugs.

Keywords: 2019-20231; Anti-T2DM candidate drugs; Anti-diabetic activity; Chemical structures; Contents; Natural products; Natural products with potential hypoglycemic activity in T2DM; T2DM.

Publication types

Review