Stress relief of chemo illness

Adam J Rose; Sarah H Lockie

doi:10.1084/jem.20240545

Stress relief of chemo illness

J Exp Med. 2024 Jul 1;221(7):e20240545. doi: 10.1084/jem.20240545. Epub 2024 May 6.

Authors

Adam J Rose¹, Sarah H Lockie²

Affiliations

¹ Nutrient Metabolism and Signalling Laboratory, Department of Biochemistry and Molecular Biology, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
² Appetite and Behavioural Control Group, Department of Physiology, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.

PMID: 38709209
PMCID: PMC11075642 (available on 2024-11-06)
DOI: 10.1084/jem.20240545

Abstract

New studies (Tang et al. 2024. J. Exp. Med.https://doi.org/10.1084/jem.20231395) describe a liver stress pathway that is activated by certain chemotherapeutic drugs, which in turn induces a peptide hormone which partially mediates the lower food intake and body weight loss during chemotherapy treatment.

MeSH terms

Animals
Antineoplastic Agents* / therapeutic use
Humans
Liver / metabolism
Neoplasms / drug therapy
Stress, Physiological

Substances

Antineoplastic Agents

Grants and funding

4519655/NH/NIH HHS/United States