Mean Blood Glucose Level During ICU Hospitalization is a Strong Predictor of the Mortality of COVID-19

Jie Hu; Lin Ouyang; Jinxiu Li; Xia Li; Yanjun Zhong; Can Hou

doi:10.2147/DMSO.S450489

Mean Blood Glucose Level During ICU Hospitalization is a Strong Predictor of the Mortality of COVID-19

Diabetes Metab Syndr Obes. 2024 May 1:17:1903-1909. doi: 10.2147/DMSO.S450489. eCollection 2024.

Authors

Jie Hu^#^{1

2}, Lin Ouyang^#³, Jinxiu Li¹, Xia Li², Yanjun Zhong¹, Can Hou²

Affiliations

¹ Critical Care Medicine Center, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
² National Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, Key Laboratory Diseases Immunology, Ministry of Education, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
³ Department of Critical Care Medicine Center, Guilin Hospital of the Second Xiangya Hospital, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.

^# Contributed equally.

Abstract

Objective: To investigate the potential prognostic value of mean blood glucose (MBG) in hospital for prognosis of COVID-19 adult patients in the intensive unit care unit (ICU).

Methods: A single-site and retrospective study enrolled 107 patients diagnosed as COVID-19 from department of critical care medicine in the Second Xiangya Hospital between October 2022 and June 2023. Demographic information including glucose during ICU hospitalization, comorbidity, clinical data, types of medications and treatment, and clinical outcome were collected. The multivariate logistic and cox regression was used to explore the relationship between blood glucose changes and clinical outcomes of COVID-19 during ICU stay.

Results: In total, 107 adult patients confirmed with COVID-19 were included. Multivariate logistic regression results showed an increase in MBG was associated with ICU mortality rate. Compared with normal glucose group (MBG <= 7.8 mmol/L), the risk of ICU mortality, 7-day mortality and 28-day mortality from COVID-19 were significantly increased in high glucose group (MBG >7.8mmol/L).

Conclusion: MBG level during ICU hospitalization was strongly correlated to all-cause mortality and co-infection in COVID-19 patients. These findings further emphasize the importance of overall glucose management in severe cases of COVID-19.

Keywords: COVID-19; ICU mortality; intensive care medicine; mean blood glucose.

Grants and funding

This work was supported by grants from Hunan Province Clinical Medical Technology Innovation Guidance (2020SK53403), Hunan Provincial Natural Science Foundation (2021JJ30931), Research Project of Hunan Provincial Health Commission (202103060770) and the China Scholarship Council (202206375025).