Microbial metabolite steers intestinal stem cell fate under stress

Shu Zhu; Wen Pan

doi:10.1016/j.stem.2024.04.006

Microbial metabolite steers intestinal stem cell fate under stress

Cell Stem Cell. 2024 May 2;31(5):591-592. doi: 10.1016/j.stem.2024.04.006.

Authors

Shu Zhu¹, Wen Pan²

Affiliations

¹ Department of Digestive Disease, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. Electronic address: zhushu@ustc.edu.cn.
² Department of Digestive Disease, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. Electronic address: wenpan@ustc.edu.cn.

PMID: 38701755
DOI: 10.1016/j.stem.2024.04.006

Abstract

Recently in Cell Metabolism, Wei et al.¹ unveiled a brain-to-gut pathway that conveys psychological stress to intestinal epithelial cells, leading to their dysfunction. This gut-brain axis involves a microbial metabolite, indole-3-acetate (IAA), as a niche signal that hampers mitochondrial respiration to skew intestinal stem cell (ISC) fate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Differentiation
Gastrointestinal Microbiome / physiology
Humans
Intestinal Mucosa / metabolism
Intestinal Mucosa / microbiology
Intestines / cytology
Intestines / microbiology
Mitochondria / metabolism
Stem Cells* / cytology
Stem Cells* / metabolism
Stress, Physiological