Steroid receptor coactivators in Treg and Th17 cell biology and function

Yosi Gilad; Ortal Shimon; Sang Jun Han; David M Lonard; Bert W O'Malley

doi:10.3389/fimmu.2024.1389041

Steroid receptor coactivators in Treg and Th17 cell biology and function

Front Immunol. 2024 Apr 18:15:1389041. doi: 10.3389/fimmu.2024.1389041. eCollection 2024.

Authors

Yosi Gilad^{1

2}, Ortal Shimon^{1

2}, Sang Jun Han^{1

2

3}, David M Lonard^{1

2

3}, Bert W O'Malley^{1

2

3}

Affiliations

¹ Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States.
² CoRegen, Inc., Baylor College of Medicine, Houston, TX, United States.
³ Nuclear Receptor, Transcription and Chromatin Biology Program, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United States.

Abstract

Steroid receptor coactivators (SRCs) are master regulators of transcription that play key roles in human physiology and pathology. SRCs are particularly important for the regulation of the immune system with major roles in lymphocyte fate determination and function, macrophage activity, regulation of nuclear factor κB (NF-κB) transcriptional activity and other immune system biology. The three members of the p160 SRC family comprise a network of immune-regulatory proteins that can function independently or act in synergy with each other, and compensate for - or moderate - the activity of other SRCs. Recent evidence indicates that the SRCs are key participants in governing numerous aspects of CD4⁺ T cell biology. Here we review findings that establish the SRCs as essential regulators of regulatory T cells (Tregs) and T helper 17 (Th17) cells, with a focus on their crucial roles in Treg immunity in cancer and Treg-Th17 cell phenotypic plasticity.

Keywords: Th17 cells; Treg cells; cell therapy; nuclear coactivators (NCoAs); steroid receptor coactivators (SRCs).

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Humans
Neoplasms / immunology
Neoplasms / metabolism
Nuclear Receptor Coactivators / metabolism
T-Lymphocytes, Regulatory* / immunology
Th17 Cells* / immunology
Th17 Cells* / metabolism

Substances

Nuclear Receptor Coactivators

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work is partly supported by funding from the National Institutes of Health grants R01 HD07857 and R01 HD08188 (BWO) and from the Adrienne Helis Malvin Foundation to DML. The authors declare that this study received funding from CoRegan Inc. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication.