Exploring potential correlations between HLA class II and the risk of microvascular complications in Japanese patients with type 1 diabetes

Eijiro Yamada; Risa Kajita; Haruna Takahashi; Kazuhiko Horiguchi; Satoshi Yoshino; Shunichi Matsumoto; Shuichi Okada; Masanobu Yamada

doi:10.1016/j.jdiacomp.2024.108763

Exploring potential correlations between HLA class II and the risk of microvascular complications in Japanese patients with type 1 diabetes

J Diabetes Complications. 2024 Apr 30;38(6):108763. doi: 10.1016/j.jdiacomp.2024.108763. Online ahead of print.

Authors

Eijiro Yamada¹, Risa Kajita², Haruna Takahashi², Kazuhiko Horiguchi², Satoshi Yoshino², Shunichi Matsumoto², Shuichi Okada², Masanobu Yamada²

Affiliations

¹ Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan. Electronic address: eijiro.yamada@gunma-u.ac.jp.
² Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.

PMID: 38696976
DOI: 10.1016/j.jdiacomp.2024.108763

Abstract

Managing complications in Type 1 diabetes (T1D) remains challenging. HLA genes, particularly DR and DQ, are linked to T1D susceptibility. We studied 48 Japanese T1D inpatients and revealed associations between DRB1*04:05-DQB1*04:01 and DRB1*09:01-DQB1*03:03 haplotypes and complications, offering a new perspective for future research.

Keywords: Complications; HLA class II; Type 1 diabetes.