Evaluation of Photobiomodulation on myocardial function of patients with advanced ischemic cardiomyopathy, A case series

Mohammadreza Razzaghi; Fatemeh Sheibani; Maryam Barati; Toktam Alirezaei; Zahra Razzaghi; Maryam Hajimoradi; Farrokh Najafi; Behzad Hajimoradi

doi:10.1016/j.pdpdt.2024.104092

Evaluation of Photobiomodulation on myocardial function of patients with advanced ischemic cardiomyopathy, A case series

Photodiagnosis Photodyn Ther. 2024 Apr 27:47:104092. doi: 10.1016/j.pdpdt.2024.104092. Online ahead of print.

Authors

Mohammadreza Razzaghi¹, Fatemeh Sheibani¹, Maryam Barati¹, Toktam Alirezaei², Zahra Razzaghi¹, Maryam Hajimoradi², Farrokh Najafi³, Behzad Hajimoradi⁴

Affiliations

¹ Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Cardiovascular department of Shohada Tajrish Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Pars Reball Co, Tehran, Iran.
⁴ Cardiovascular department of Shohada Tajrish Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: bhajimoradi@yahoo.com.

PMID: 38685548
DOI: 10.1016/j.pdpdt.2024.104092

Abstract

Background: Heart failure is a growing cardiovascular disease burden with high mortality rates, primarily attributed to myocardial ischemia. Previous studies have shown promising effects of Photobiomodulation in heart failure treatment. In this study, we aimed to investigate the effect of Photobiomodulation on myocardial function of patients with advanced ischemic heart failure.

Method: A non-randomized case series study involving 10 advanced heart failure patients was conducted. Patients received 15 sessions of transcutaneous and intravenous Photobiomodulation therapy using low-level red (658 nm) and infrared lasers (810 nm). All participants were evaluated by six-minute walk tests, dyspnea function classes, and echocardiography. 3 months after the sessions, the mentioned tests were reevaluated RESULT: The study included ten cardiomyopathic patients, 90 % male and the mean age was 63.20±6.01 years. The six-minute walk test change and shortness of breath function class change has 0.852 (p-value=0.006) correlation and the correlation between the Six-minute walk test change and the Systolic ejection fraction rate change, was 0.73 (p-value=0.025).

Conclusion: Based on the results of the study, it can be concluded that interventions in cardiomyopathic patients have shown promising improvements in certain cardiac function parameters. Specifically, the significant enhancement in the six-minute walk test post-intervention (p = 0.013) suggests a positive impact on functional capacity. Although the increase in systolic ejection fraction rate was not statistically significant (p = 0.197), the correlations identified provide valuable insights into the interplay between variables such as shortness of breath function class and the six-minute walk test. These findings underscore the complexity of managing cardiomyopathy and highlight the importance of further research to elucidate the relationships between different clinical parameters and patient outcomes in this population.

Keywords: Heart failure; Ischemic heart disease; Photobiomodulation; Six minute walk test.