Description of Aspartate Aminotransferase and Alanine Aminotransferase in Burn Patients at the Burn Unit of Dr. Hasan Sadikin General Hospital (Rshs) Bandung

Ann Burns Fire Disasters. 2023 Sep 30;36(3):217-221. eCollection 2023 Sep.

Abstract
in English, French

Burn injury is trauma with several metabolic reactions including hepatocytes that can cause apoptosis and necrosis. Proliferation occurs to compensate for this reaction but complicates with the loss of protein of the injury. The aim of this study is to describe the level of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in burn injury. This study was a descriptive retrospective design using secondary data from medical records of patients at the Burns Unit of Dr. Hasan Sadikin Hospital Bandung (RSHS) in the period August 2017 to July 2019. Total samples in this study were 116 people. Normal level of AST and ALT was found in 23 people (19.8%), elevation of AST in 31 people (26.7%), elevation of ALT in 5 people (4.3%) and elevation of both AST and ALT in 57 people (41.3%). Increased levels of AST and ALT mostly occurred in men (51%), aged 45 years (56%), with injury due to electricity (26%), 20-29% burn area (32%), and occurred in the first week of wound onset. Most cases of burn injury showed increasing levels of AST and ALT. This might be due to the metabolism of hepatocytes in burn cases. Elevation of AST and ALT was mainly found in burn injury cases at RSHS notably in the first week of onset. Further research is needed to verify the relation of this condition. Elevated levels of AST and ALT should be the consideration of clinicians in giving therapy.

La brûlure cause des troubles métaboliques pouvant conduire à une cytolyse hépatique. La prolifération cellulaire subséquente est la cause d’une perte protidique. Cette étude a pour but d’évaluer les niveaux d’AST et d’ALT après brûlure. Il s’agit d’une étude rétrospective à partir des dossiers de 116 patients hospitalisés dans le CTB de l’HGHS entre août 2017 et juillet 2019. Vingt-trois (19,8%) patients avaient des résultats normaux, 31 (26,7%) une élévation isolée d’AST, 5 (4,3) une élévation isolée d’ALT et 57 (41,3%) une élévation des 2 enzymes. Ces élévations étaient observés dans la première semaine, plus fréquemment chez les hommes (51%) après brûlure électrothermique (26%). L’âge se situait autour de 45 ans et une surface brûlée de 20 à 29% était le plus souvent observée (32%). Ces élévation corrèlent probablement avec la brûlure mais des études complémentaires sont nécessaires pour vérifier cette hypothèse et proposer un traitement.

Keywords: alanine aminotransferase; aspartate aminotransferase; burn injury.