Diagnostic and therapeutic value of human serpin family proteins

Sabina Janciauskiene; Urszula Lechowicz; Magdalena Pelc; Beata Olejnicka; Joanna Chorostowska-Wynimko

doi:10.1016/j.biopha.2024.116618

Diagnostic and therapeutic value of human serpin family proteins

Biomed Pharmacother. 2024 Apr 27:175:116618. doi: 10.1016/j.biopha.2024.116618. Online ahead of print.

Authors

Sabina Janciauskiene¹, Urszula Lechowicz², Magdalena Pelc², Beata Olejnicka³, Joanna Chorostowska-Wynimko⁴

Affiliations

¹ Department of Pulmonary and Infectious Diseases and BREATH German Center for Lung Research (DZL), Hannover Medical School, Hannover, Germany; Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, 26 Plocka St, Warsaw 01-138, Poland.
² Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, 26 Plocka St, Warsaw 01-138, Poland.
³ Department of Pulmonary and Infectious Diseases and BREATH German Center for Lung Research (DZL), Hannover Medical School, Hannover, Germany.
⁴ Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, 26 Plocka St, Warsaw 01-138, Poland. Electronic address: j.chorostowska@igichp.edu.pl.

PMID: 38678961
DOI: 10.1016/j.biopha.2024.116618

Abstract

SERPIN (serine proteinase inhibitors) is an acronym for the superfamily of structurally similar proteins found in animals, plants, bacteria, viruses, and archaea. Over 1500 SERPINs are known in nature, while only 37 SERPINs are found in humans, which participate in inflammation, coagulation, angiogenesis, cell viability, and other pathophysiological processes. Both qualitative or quantitative deficiencies or overexpression and/or abnormal accumulation of SERPIN can lead to diseases commonly referred to as "serpinopathies". Hence, strategies involving SERPIN supplementation, elimination, or correction are utilized and/or under consideration. In this review, we discuss relationships between certain SERPINs and diseases as well as putative strategies for the clinical explorations of SERPINs.

Keywords: Hereditary diseases; Inflammation; Protease inhibitors; SERPINs; Serpinopathies; Therapeutics.

Publication types

Review