miRNAs dysregulation in ankylosing spondylitis: A review of implications for disease mechanisms, and diagnostic markers

Osama A Mohammed; Mushabab Alghamdi; Masoud I E Adam; Waad Fuad BinAfif; Jaber Alfaifi; Mohannad Mohammad S Alamri; Abdullah Ali Alqarni; Abdullah Hassan Alhalafi; Emad Bahashwan; AbdulElah Al Jarallah AlQahtani; Abdullah Ayed; Rania H Hassan; Mustafa Ahmed Abdel-Reheim; Sherif S Abdel Mageed; Assad Ali Rezigalla; Ahmed S Doghish

doi:10.1016/j.ijbiomac.2024.131814

miRNAs dysregulation in ankylosing spondylitis: A review of implications for disease mechanisms, and diagnostic markers

Int J Biol Macromol. 2024 Apr 26;268(Pt 2):131814. doi: 10.1016/j.ijbiomac.2024.131814. Online ahead of print.

Authors

Osama A Mohammed¹, Mushabab Alghamdi², Masoud I E Adam³, Waad Fuad BinAfif⁴, Jaber Alfaifi⁵, Mohannad Mohammad S Alamri⁶, Abdullah Ali Alqarni⁴, Abdullah Hassan Alhalafi⁶, Emad Bahashwan⁷, AbdulElah Al Jarallah AlQahtani⁷, Abdullah Ayed⁸, Rania H Hassan⁹, Mustafa Ahmed Abdel-Reheim¹⁰, Sherif S Abdel Mageed¹¹, Assad Ali Rezigalla¹², Ahmed S Doghish¹³

Affiliations

¹ Department of Pharmacology, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.
² Department of Internal Medicine, Division of Rheumatology, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.
³ Department of Medical Education and Internal Medicine, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.
⁴ Department of Internal Medicine, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.
⁵ Department of Child Health, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.
⁶ Department of Family and Community Medicine, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.
⁷ Department of Internal Medicine, Division of Dermatology, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.
⁸ Department of Surgery, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.
⁹ Dermatology Clinic, Abbasseya Psychiatric Hospital, Abbasseya, Cairo 11517, Egypt.
¹⁰ Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni Suef 62521, Egypt. Electronic address: m.ahmed@su.edu.sa.
¹¹ Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
¹² Department of Anatomy, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.
¹³ Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt. Electronic address: ahmed_doghish@azhar.edu.eg.

PMID: 38677679
DOI: 10.1016/j.ijbiomac.2024.131814

Abstract

Epigenetic processes, including non-coding RNA, histone modifications, and DNA methylation, play a vital role in connecting the environment to the development of a disorder, especially when there is a favorable genetic background. Ankylosing Spondylitis (AS) is a chronic type of spinal arthritis that highlights the significance of epigenetics in diseases related to autoimmunity and inflammation. MicroRNAs (miRNAs) are small non-coding RNAs that are involved in both normal and aberrant pathological and physiological gene expression. This study focuses on the pathophysiological pathways to clarify the role of miRNAs in AS. We have conducted a thorough investigation of the involvement of miRNAs in several processes, including inflammation, the production of new bone, T-cell activity, and the regulation of pathways such as BMP, Wnt, and TGFβ signaling. Undoubtedly, miRNAs play a crucial role in enhancing our comprehension of the pathophysiology of AS, and their promise as a therapeutic strategy is quickly expanding.

Keywords: Ankylosing spondylitis; Pathogenesis; miRNAs.

Publication types

Review