InsT-ALLing CD7 chimeric antigen receptors before transplantation

Br J Haematol. 2024 Apr 26. doi: 10.1111/bjh.19498. Online ahead of print.

Abstract

In their paper, the authors present their experience with the use of chimeric antigen receptor T cells targeting CD7 as a bridge to allogeneic haematopoietic cell transplantation in patients with relapsed/refractory T-cell acute lymphoblastic leukaemia/lymphoblastic lymphoma. Commentary on: Cao et al. A safety and efficacy study of allogeneic haematopoietic stem cell transplantation for refractory and relapsed T-cell acute lymphoblastic leukaemia/lymphoblastic lymphoma patients who achieved complete remission after autologous CD7 chimeric antigen receptor T-cell therapy. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19445.

Keywords: CD7 CARs; T‐ALL; allogeneic haematopoietic cell transplantation.