Home Meal Replacement Fortified with Eggshell Powder and Vitamin D Prevents Bone Loss in Postmenopausal Women: A Randomized, Double-Blind, Controlled Study

Nutrients. 2024 Apr 12;16(8):1152. doi: 10.3390/nu16081152.

Abstract

Calcium and vitamin D deficiencies have been ongoing problems in Koreans due to a lack of food sources of calcium and vitamin D. Postmenopausal women aged 50 to 64 years (n = 25) were randomly assigned to consume three home meal replacements (HMRs)/week with (treatment) and without (control) eggshell powder and vitamin D for 6 months. Additionally, subjects who agreed to continue the study consumed the same three HMRs/week for an additional 6 months in this randomized double-blind study. We confirmed the high compliance of the study participants by analyzing carotenoids, the bioactive substances of HMRs, in the blood. The treatment group consumed an additional 261 mg/d of calcium and 10.3 μg/d of vitamin D from the HMRs, thus meeting the recommended intakes of calcium and vitamin D for Koreans. As a result of consuming fortified HMRs for 6 months, the decline in femoral neck bone density was significantly reduced in the treatment group (p = 0.035). This study indicates that inexpensive eggshell powder may be a good source of calcium for populations with low consumption of milk and dairy products. Additionally, functional HMRs fortified with eggshell powder and vitamin D can be a good dietary strategy for bone health.

Keywords: bone mineral density; natural calcium; parathyroid hormone.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Animals
  • Bone Density / drug effects
  • Calcium, Dietary* / administration & dosage
  • Double-Blind Method
  • Egg Shell*
  • Female
  • Food, Fortified*
  • Humans
  • Meals
  • Middle Aged
  • Osteoporosis, Postmenopausal* / prevention & control
  • Postmenopause*
  • Powders
  • Republic of Korea
  • Vitamin D* / administration & dosage
  • Vitamin D* / blood

Substances

  • Vitamin D
  • Calcium, Dietary
  • Powders