Role of microenvironment on muscle stem cell function in health, adaptation, and disease

Daniel Helzer; Pranav Kannan; Joseph C Reynolds; Devin E Gibbs; Rachelle H Crosbie

doi:10.1016/bs.ctdb.2024.02.002

Role of microenvironment on muscle stem cell function in health, adaptation, and disease

Curr Top Dev Biol. 2024:158:179-201. doi: 10.1016/bs.ctdb.2024.02.002. Epub 2024 Mar 13.

Authors

Daniel Helzer¹, Pranav Kannan¹, Joseph C Reynolds¹, Devin E Gibbs², Rachelle H Crosbie³

Affiliations

¹ Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States.
² Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, United States.
³ Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, United States; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, United States; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States. Electronic address: rcrosbie@physci.ucla.edu.

PMID: 38670705
DOI: 10.1016/bs.ctdb.2024.02.002

Abstract

The role of the cellular microenvironment has recently gained attention in the context of muscle health, adaption, and disease. Emerging evidence supports major roles for the extracellular matrix (ECM) in regeneration and the dynamic regulation of the satellite cell niche. Satellite cells normally reside in a quiescent state in healthy muscle, but upon muscle injury, they activate, proliferate, and fuse to the damaged fibers to restore muscle function and architecture. This chapter reviews the composition and mechanical properties of skeletal muscle ECM and the role of these factors in contributing to the satellite cell niche that impact muscle regeneration. In addition, the chapter details the effects of satellite cell-matrix interactions and provides evidence that there is bidirectional regulation affecting both the cellular and extracellular microenvironment within skeletal muscle. Lastly, emerging methods to investigate satellite cell-matrix interactions will be presented.

Keywords: Extracellular matrix; Myoscaffolds; Satellite cell; Stem cell.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adaptation, Physiological
Animals
Cellular Microenvironment*
Extracellular Matrix* / metabolism
Humans
Muscle, Skeletal* / cytology
Muscle, Skeletal* / physiology
Muscular Diseases / pathology
Muscular Diseases / physiopathology
Regeneration / physiology
Satellite Cells, Skeletal Muscle* / cytology
Satellite Cells, Skeletal Muscle* / metabolism
Satellite Cells, Skeletal Muscle* / physiology
Stem Cell Niche / physiology
Stem Cells / cytology
Stem Cells / physiology