Acid etching post-treatment enhanced fungal sterilization performance of copper-manganese-cerium oxide in liquid and aerosol: Materials and molecular biological mechanisms

Zhao Chen; Jiadong Liu; Zhiyi Li; Peiyuan Zheng; Bo Gao; Saleh Al-Farraj; Mika Sillanpää

doi:10.1016/j.jhazmat.2024.134372

Acid etching post-treatment enhanced fungal sterilization performance of copper-manganese-cerium oxide in liquid and aerosol: Materials and molecular biological mechanisms

J Hazard Mater. 2024 Jun 5:471:134372. doi: 10.1016/j.jhazmat.2024.134372. Epub 2024 Apr 20.

Authors

Zhao Chen¹, Jiadong Liu², Zhiyi Li³, Peiyuan Zheng¹, Bo Gao¹, Saleh Al-Farraj⁴, Mika Sillanpää⁵

Affiliations

¹ Key Laboratory of Northwest Water Resource, Environment and Ecology, MOE, Xi'an University of Architecture and Technology, Xi'an 710055, China; Key Laboratory of Membrane Separation of Shaanxi Province, Xi'an University of Architecture and Technology, Xi'an 710055, China.
² Key Laboratory of Northwest Water Resource, Environment and Ecology, MOE, Xi'an University of Architecture and Technology, Xi'an 710055, China; Key Laboratory of Membrane Separation of Shaanxi Province, Xi'an University of Architecture and Technology, Xi'an 710055, China. Electronic address: liujiadong@xauat.edu.cn.
³ Powerchina Northwest Engineering Corporation Limited, Xi'an 710065, China.
⁴ Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
⁵ Department of Biological and Chemical Engineering, Aarhus University, Nørrebrogade 44, 8000 Aarhus C, Denmark.

PMID: 38669933
DOI: 10.1016/j.jhazmat.2024.134372

Abstract

Bioaerosol is one of the main ways to spread respiratory infectious diseases. In order to further improve the sterilization efficiency of copper-manganese-cerium oxide (CuMnCeO_x), the post-treatment method based on acid etching was adopted. The results showed that sterilization efficiency of the treated CuMnCeOx could reach 99% in aerosol with space velocity of 1400 h^-1. L(+)-ascorbic acid successfully promoted the formation of Cu⁺, oxygen vacancies and the generation of reactive oxygen species (ROS) on the surface of the treated CuMnCeO_x. During sterilization in liquid system, the transcriptome identified 316 differentially expressed genes, including 270 up-regulated genes and 46 down-regulated genes. Differentially expressed genes were significantly enriched in cell wall (GO:0005618) and external encapsulating structure (GO:0030312). Up-regulated genes were shown in regulation of reactive oxygen species biosynthetic processes (GO:1903409, GO:1903426, GO:1903428) and positive regulation all of reactive oxygen species metabolic process (GO:2000379), indicating that ROS induced cell death by destroying cell wall.

Keywords: Bioaerosols; Fungal sterilization; Metal oxide; Modification strategy; Reactive oxygen species.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aerosols*
Copper* / chemistry
Manganese* / chemistry
Oxides / chemistry
Reactive Oxygen Species* / metabolism
Sterilization* / methods
Transcriptome / drug effects

Substances

Aerosols
Copper
Reactive Oxygen Species
Manganese
Oxides