Mitochondrial sites of contact with the nucleus

J Cell Biol. 2024 Jun 3;223(6):e202305010. doi: 10.1083/jcb.202305010. Epub 2024 Apr 26.

Abstract

Membrane contact sites (MCS) between mitochondria and the nucleus have been recently described. Termed nucleus associated mitochondria (NAM), they prime the expression of genes required for cellular resistance to stressors, thus offering a tethering mechanism for homeostatic communication. Here, we discuss the composition of NAM and their physiological and pathological significance.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Nucleus* / genetics
  • Cell Nucleus* / metabolism
  • Eukaryotic Cells / cytology
  • Humans
  • Mitochondria* / genetics
  • Mitochondria* / metabolism
  • Mitochondrial Membranes / metabolism