Nuclear Phospholipids and Signaling: An Update of the Story

Irene Casalin; Eleonora Ceneri; Stefano Ratti; Lucia Manzoli; Lucio Cocco; Matilde Y Follo

doi:10.3390/cells13080713

Nuclear Phospholipids and Signaling: An Update of the Story

Cells. 2024 Apr 19;13(8):713. doi: 10.3390/cells13080713.

Authors

Irene Casalin¹, Eleonora Ceneri¹, Stefano Ratti¹, Lucia Manzoli¹, Lucio Cocco¹, Matilde Y Follo¹

Affiliation

¹ Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.

Abstract

In the last three decades, the presence of phospholipids in the nucleus has been shown and thoroughly investigated. A considerable amount of interest has been raised about nuclear inositol lipids, mainly because of their role in signaling acting. Here, we review the main issues of nuclear phospholipid localization and the role of nuclear inositol lipids and their related enzymes in cellular signaling, both in physiological and pathological conditions.

Keywords: brain; muscle; myelodysplastic neoplasms (MDS); nucleus; phosphoinositides; phospholipases C.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Nucleus* / metabolism
Humans
Phospholipids* / metabolism
Signal Transduction*

Substances

Phospholipids

Grants and funding

The publication was supported by the International Visegrad Fund through Visegrad Grants within the project “Inclusion of Young Researchers from the V4 Region in Top Research on the Cell Nucleus” (project ID 22230207). The publication was supported by Italian PRIN-MIUR grants (to L.M. and M.Y.F.), Fondazione Cassa di Risparmio di Bologna grant (to M.Y.F.), Fondazione del Monte di Bologna e Ravenna grant (to L.C.)