Crosstalk between Exercise and Immunotherapy: Current Understanding and Future Directions

Jiwei Liu; Weici Liu; Yuan Wan; Wenjun Mao

doi:10.34133/research.0360

Crosstalk between Exercise and Immunotherapy: Current Understanding and Future Directions

Research (Wash D C). 2024 Apr 25:7:0360. doi: 10.34133/research.0360. eCollection 2024.

Authors

Jiwei Liu^{1

2}, Weici Liu^{1

2}, Yuan Wan³, Wenjun Mao^{1

2}

Affiliations

¹ Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China.
² Wuxi College of Clinical Medicine, Nanjing Medical University, Wuxi 214023, China.
³ The Pq Laboratory of BiomeDx/Rx, Department of Biomedical Engineering, Binghamton University, Binghamton, NY 13850, USA.

Abstract

Accumulated evidence highlights that exercise can modulate multiple cytokines, influencing transcriptional pathways, and reprogramming certain metabolic processes, ultimately promoting antitumor immunity and enhancing the efficacy of immune checkpoint inhibitors in cancer patients. Exploring the mechanisms behind this will, for one thing, help us uncover key factors and pathways in exercise-assisted cancer immunotherapy, offering more possibilities for future treatment methods. For another, it will support the development of more personalized and effective exercise prescriptions, thereby improving the prognosis of cancer patients.

Abstract

Grants and funding