Interleukin‑18 binding protein: Biological properties and roles in human and animal immune regulation (Review)

Fengxue Wang

doi:10.3892/br.2024.1775

Interleukin‑18 binding protein: Biological properties and roles in human and animal immune regulation (Review)

Biomed Rep. 2024 Apr 9;20(6):87. doi: 10.3892/br.2024.1775. eCollection 2024 Jun.

Author

Fengxue Wang¹

Affiliation

¹ College of Veterinary Medicine, Key Laboratory for Clinical Diagnosis and Treatment of Animal Disease at the Ministry of Agriculture, Inner Mongolia Agricultural University, Inner Mongolia Autonomous Region, Huhhot 010018, P.R. China.

Abstract

IL-18 binding protein (IL-18BP) is a natural regulatory molecule of the proinflammatory cytokine IL-18. It can regulate activity of IL-18 by high affinity binding. The present review aimed to highlight developments, characteristics and functions of IL-18BP. IL-18BP serves biological and anti-pathological roles in treating disease. In humans, it modulates progression of a number of chronic diseases, such as adult-onset Still's disease. The present review summarizes molecular structure, role of IL-18BP in disease and interaction with other proteins in important pathological processes.

Keywords: immune regulation; interferon-γ; interleukin-18 binding protein.

Publication types

Review

Grants and funding

Funding: The preset study was supported by the Inner Mongolia Agricultural University Young Teachers Research Ability Promotion Project (grant no. BR220113) and the Education Department of the Inner Mongolia Autonomous Region ‘Young Scientific and Technological Talents in Universities’ Project (grant no. NJYT22043).