Randomized controlled clinical trial on the efficacy of a novel antimicrobial chewing gum in reducing plaque and gingivitis in adolescent orthodontic patients

Clin Oral Investig. 2024 Apr 25;28(5):272. doi: 10.1007/s00784-024-05669-4.

Abstract

Objectives: Chewing gums containing antiseptics or other antimicrobial substances may be effective in reducing plaque and gingivitis. Therefore, the aim of this randomized placebo-controlled clinical trial was to investigate the efficacy of a novel antimicrobial chewing gum containing essential oils (cinnamon, lemon, peppermint) and extracts on reduction of dental plaque and gingivitis as well as on oral health-related quality of life (OHRQoL) in adolescent orthodontic patients.

Materials: 52 patients (11-22 years of age) were randomly assigned to use a test chewing gum (COVIDGUM, Clevergum) or a commercially available control chewing gum over a period of 10 days. Approximal plaque index (API), papillary bleeding index (PBI) and an OHRQoL questionnaire for children (COHIP-G19) were assessed at baseline (BL), after 10 days (10d) and 30 days (30d). In addition, oral health and oral hygiene related questions of the COHIP-G19 questionnaire were evaluated separately in subscales at each timepoint. Data were analyzed using non-parametrical statistical procedures (α = 0.05).

Results: API and PBI decreased significantly over time from BL to 10d and from BL to 30d in both groups, without significant differences between the groups. In both groups, the COHIP-G19 score, oral health subscale and oral hygiene subscale decreased significantly over time. Regarding the oral hygiene subscale, the test group showed significantly better scores at 30d (p = 0.011).

Conclusion: Both chewing gums performed similarly effective in terms of reducing plaque accumulation and gingival inflammation and improving OHRQoL.

Clinical relevance: Chewing gums without antimicrobial ingredients may be sufficient to decrease plaque accumulation and gingival inflammation.

Keywords: Chewing gum; Essential oil; Gingivitis; Orthodontic treatment; Plaque accumulation.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Anti-Infective Agents / therapeutic use
  • Chewing Gum*
  • Child
  • Dental Plaque Index
  • Dental Plaque* / prevention & control
  • Female
  • Gingivitis* / prevention & control
  • Humans
  • Male
  • Oils, Volatile / therapeutic use
  • Periodontal Index
  • Quality of Life*
  • Surveys and Questionnaires
  • Treatment Outcome
  • Young Adult

Substances

  • Chewing Gum
  • Anti-Infective Agents
  • Oils, Volatile