Skin fibrosis diseases mainly include hypertrophic scar, keloid, and systemic sclerosis, etc. The main pathological features are excessive activation of fibroblasts and abnormal deposition of extracellular matrix. In recent years, studies have shown that aerobic glycolysis is closely related to the occurrence and development of skin fibrosis diseases. Drugs targeting aerobic glycolysis has provided new ideas for skin anti-fibrosis treatment. This article reviews the role of enzymes and products related to aerobic glycolysis in the occurrence and development of skin fibrosis diseases and the drugs targeting aerobic glycolysis for the treatment of skin fibrosis diseases.
皮肤纤维化疾病主要包括增生性瘢痕、瘢痕疙瘩及系统性硬化病等，其主要病理特点为成纤维细胞过度激活和细胞外基质异常沉积。近年来研究表明，有氧糖酵解与皮肤纤维化疾病的发生与发展密切相关，以有氧糖酵解为治疗靶点的药物为皮肤抗纤维化治疗提供了新的思路。该文就有氧糖酵解相关酶和产物在皮肤纤维化疾病发生与发展中的作用及靶向有氧糖酵解治疗皮肤纤维化疾病的药物进行综述。.