Dihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris

Phytochemistry. 2024 Jun:222:114107. doi: 10.1016/j.phytochem.2024.114107. Epub 2024 Apr 23.

Abstract

The isolation of previously undescribed 12 compounds from the MeOH extract of Jacobaea vulgaris whole plants is disclosed, comprising 11 dihydrostilbenes (1-11) and one flavanone (12), and eight known compounds (six flavonoids, one dihydrostilbene, and one caffeoylquinic acid). Structural elucidation employed spectroscopic methods, including 1D and 2D NMR spectroscopy, HRESIMS, and ECD calculations. Evaluation of the compounds' effects on PCSK9 and LDLR mRNA expression revealed that compounds 1 and 3 downregulated PCSK9 mRNA while increasing LDLR mRNA expression, suggesting potential cholesterol-lowering properties.

Keywords: Asteraceae; Dihydrostilbenes; Flavonoids; Jacobaea vulgaris; LDLR; PCSK9.

MeSH terms

  • Flavonoids* / chemistry
  • Flavonoids* / isolation & purification
  • Flavonoids* / pharmacology
  • Humans
  • Molecular Structure
  • Proprotein Convertase 9 / genetics
  • Proprotein Convertase 9 / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptors, LDL / metabolism
  • Stilbenes* / chemistry
  • Stilbenes* / isolation & purification
  • Stilbenes* / pharmacology

Substances

  • Flavonoids
  • Stilbenes
  • Proprotein Convertase 9
  • Receptors, LDL
  • PCSK9 protein, human
  • LDLR protein, human
  • RNA, Messenger