During May-July 2023, a cluster of 7 patients at local hospitals in Florida, USA, received a diagnosis of Plasmodium vivax malaria. Whole-genome sequencing of the organism from 4 patients and phylogenetic analysis with worldwide representative P. vivax genomes indicated probable single parasite introduction from Central/South America.
Keywords: Florida; Plasmodium vivax; United States; autochthonous; genome; local transmission; malaria; origin; parasite introduction; parasites; vector-borne infections.