A study demonstrating users' preference for the adapted-REQUITE patient-reported outcome questionnaire over PRO-CTCAE® in patients with lung cancer

Thomas Jordan; Thitikorn Nuamek; Isabella Fornacon-Wood; Raffaele Califano; Joanna Coote; Margaret Harris; Hitesh Mistry; Paul Taylor; David Woolf; Corinne Faivre-Finn

doi:10.3389/fonc.2024.1328871

A study demonstrating users' preference for the adapted-REQUITE patient-reported outcome questionnaire over PRO-CTCAE^® in patients with lung cancer

Front Oncol. 2024 Apr 10:14:1328871. doi: 10.3389/fonc.2024.1328871. eCollection 2024.

Authors

Thomas Jordan^{1

2

3}, Thitikorn Nuamek², Isabella Fornacon-Wood^{1

2}, Raffaele Califano^{1

2}, Joanna Coote², Margaret Harris², Hitesh Mistry¹, Paul Taylor², David Woolf², Corinne Faivre-Finn^{1

2}

Affiliations

¹ Division of Cancer Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, United Kingdom.
² The Christie NHS Foundation Trust, Manchester, United Kingdom.
³ Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust, Wigan, United Kingdom.

Abstract

Introduction: The use of patient-reported outcomes (PROs) has been shown to enhance the accuracy of symptom collection and improve overall survival and quality of life. This is the first study comparing concordance and patient preference for two PRO tools: Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE^®) and the adapted-REQUITE Lung Questionnaire.

Materials and methods: Patients with lung cancer were recruited to the study while attending outpatient clinics at a tertiary cancer centre. Clinician-reported outcomes were generated through initial patient assessment with CTCAE v4.03. Participants then completed the PRO-CTCAE^® and adapted-REQUITE questionnaires. Concordance between the 2 questionnaires was assessed by calculating Pearson correlation coefficient. PRO-CTCAE^® and CTCAE concordance was demonstrated by calculating Pearson correlation coefficient from the linear predictors of an ordinal logistic regression. P-values were also calculated.

Results: Out of 74 patients approached, 65 provided written informed consent to participate in the study. 63 (96.9%) patients completed both PRO-CTCAE^® and adapted-REQUITE questionnaires. Pearson correlation coefficient between PRO tools was 0.8-0.83 (p <.001). Correlation between CTCAE and PRO-CTCAE^® ranged between 0.66-0.82 (p <.001). Adapted-REQUITE and CTCAE correlation was higher for all symptoms ranging between 0.79-0.91 (p <.001). Acceptable discrepancies within one grade were present in 96.8%-100% of symptom domains for REQUITE and in 92.1%-96.8% for all domains in the PRO-CTCAE^®. 54% of the total participant cohort favored the adapted-REQUITE questionnaire due to reduced subjectivity in the questions and ease of use.

Conclusion: The adapted-REQUITE questionnaire has shown a superior correlation to clinician-reported outcomes and higher patient preference than the PRO-CTCAE^®. The results of this study suggest the use of the REQUITE questionnaire for patients with lung cancer in routine clinical practice.

Keywords: CTCAE; REQUITE; lung cancer; patient reported outcome; quality of life; symptoms.

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.