A proof of concept: digital diary using 24-hour monitoring using wearable device for patients with Parkinson's disease in nursing homes

Hikaru Kamo; Genko Oyama; Yui Yamasaki; Tomohiro Nagayama; Ryotatsu Nawashiro; Nobutaka Hattori

doi:10.3389/fneur.2024.1356042

A proof of concept: digital diary using 24-hour monitoring using wearable device for patients with Parkinson's disease in nursing homes

Front Neurol. 2024 Apr 10:15:1356042. doi: 10.3389/fneur.2024.1356042. eCollection 2024.

Authors

Hikaru Kamo¹, Genko Oyama^{1

2

3

4

5}, Yui Yamasaki⁶, Tomohiro Nagayama⁶, Ryotatsu Nawashiro⁶, Nobutaka Hattori^{1

2

3

4

5

7

8}

Affiliations

¹ Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
² Department of Home Medical Care System, Based on Information and Communication Technology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
³ Department of Drug Development for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁴ Department of PRO-Based Integrated Data Analysis in Neurological Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁵ Research and Therapeutics for Movement Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁶ Sunwels Company Limited, Chiyoda-ku, Tokyo, Japan.
⁷ Research Institute of Disease of Old Age, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
⁸ Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Saitama, Japan.

Abstract

Introduction: In the advanced stages of Parkinson's disease (PD), motor complications such as wearing-off and dyskinesia are problematic and vary daily. These symptoms need to be monitored precisely to provide adequate care for patients with advanced PD.

Methods: This study used wearable devices to explore biomarkers for motor complications by measuring multiple biomarkers in patients with PD residing in facilities and combining them with lifestyle and clinical assessments. Data on the pulse rate and activity index (metabolic equivalents) were collected from 12 patients over 30 days.

Results: The pulse rate and activity index during the off- and on-periods and dyskinesia were analyzed for two participants; the pulse rate and activity index did not show any particular trend in each participant; however, the pulse rate/activity index was significantly greater in the off-state compared to that in the dyskinesia and on-states, and this index in the dyskinesia state was significantly greater than that in the on-state in both participants.

Conclusion: These results suggest the pulse rate and activity index combination would be a useful indicator of wearing-off and dyskinesia and that biometric information from wearable devices may function as a digital diary. Accumulating more cases and collecting additional data are necessary to verify our findings.

Keywords: Parkinson’s disease; dyskinesia; heart rate; physiological biomarker; wearable device; wearing off.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was partially supported by JSPS KAKENHI Grant Numbers 23K19409 and 21K12711. Department of Home Medical Care System, Based on Information and Communication Technology, Juntendo University Graduate School of Medicine is a collaborative research program supported by Sunwels Ltd.