Zeolitic imidazolate framework-8: a versatile nanoplatform for tissue regeneration

Zhixin Li; Yinjin Shao; Youwen Yang; Jun Zan

doi:10.3389/fbioe.2024.1386534

Zeolitic imidazolate framework-8: a versatile nanoplatform for tissue regeneration

Front Bioeng Biotechnol. 2024 Apr 9:12:1386534. doi: 10.3389/fbioe.2024.1386534. eCollection 2024.

Authors

Zhixin Li¹, Yinjin Shao¹, Youwen Yang², Jun Zan²

Affiliations

¹ Department of Rehabilitation, Ganzhou People's Hospital, Ganzhou, China.
² Institute of Additive Manufacturing, Jiangxi University of Science and Technology, Nanchang, China.

Abstract

Extensive research on zeolitic imidazolate framework (ZIF-8) and its derivatives has highlighted their unique properties in nanomedicine. ZIF-8 exhibits advantages such as pH-responsive dissolution, easy surface functionalization, and efficient drug loading, making it an ideal nanosystem for intelligent drug delivery and phototherapy. These characteristics have sparked significant interest in its potential applications in tissue regeneration, particularly in bone, skin, and nerve regeneration. This review provides a comprehensive assessment of ZIF-8's feasibility in tissue engineering, encompassing material synthesis, performance testing, and the development of multifunctional nanosystems. Furthermore, the latest advancements in the field, as well as potential limitations and future prospects, are discussed. Overall, this review emphasizes the latest developments in ZIF-8 in tissue engineering and highlights the potential of its multifunctional nanoplatforms for effective complex tissue repair.

Keywords: biocompatibility; drug delivery; tissue regeneration; versatile nanoplatform; zeolitic imidazolate framework.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by the following funds: 1) The Natural Science Foundation of China (51935014, 52365046, 52105352, and 82072084); 2) National Key Research and Development Program of China (2023YFB4605800); 3) JiangXi Provincial Natural Science Foundation of China (20224ACB204013); 4) Shccig- Qinling Program (2022360702014891).