Differential activation of basal and IL-7-induced PI3K/Akt/mTOR and JAK/STAT5 signaling distinguishes pediatric from adult acute lymphoblastic leukemia
Haematologica. 2024 Apr 24.
doi: 10.3324/haematol.2023.284102.
Online ahead of print.
1 Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa.
2 Hospital dos Capuchos, Lisboa.
3 Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal; Champalimaud Centre for the Unknown, Lisboa.
4 Hematology Laboratory, Saint-Louis Hospital, AP-HP, Paris, France; Saint-Louis Research Institute, Université de Paris, INSERM U944/Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 7212, Paris.
5 Département de Génétique, Unité de Génétique Moléculaire, Hôpital Robert Debré, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France; INSERM UMR_S1131, Institut de Recherche Saint-Louis, Université Paris-Cité, Paris.
6 Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa.
7 Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Portugal; University of Bologna, Department of Biomedical and Neuromotor Sciences.
8 University of Bologna, Department of Biomedical and Neuromotor Sciences.
9 Saint-Louis Research Institute, Université de Paris, INSERM U944/Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 7212, Paris, France; Département de Génétique, Unité de Génétique Moléculaire, Hôpital Robert Debré, Assistance Publique des Hôpitaux de Paris (APHP), Paris.
10 Champalimaud Centre for the Unknown, Lisboa, Portugal; Hematology Laboratory, Saint-Louis Hospital, AP-HP, Paris.
11 Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa. joao_barata@medicina.ulisboa.pt.