Prognostic factors of adrenocortical carcinoma in children and adolescents: a population-based study

Zhihua Jiang; Bi Zhou; Caiyun Zhang; Chen Wang

doi:10.1007/s11255-024-04063-z

Prognostic factors of adrenocortical carcinoma in children and adolescents: a population-based study

Int Urol Nephrol. 2024 Apr 23. doi: 10.1007/s11255-024-04063-z. Online ahead of print.

Authors

Zhihua Jiang^#¹, Bi Zhou^#², Caiyun Zhang³, Chen Wang⁴

Affiliations

¹ Department of Plastic Surgery, Hangzhou Children's Hospital, Hangzhou, 310005, Zhejiang, China.
² Department of Pediatrics, Suzhou Hospital of Anhui Medical University, Suzhou, Anhui, China.
³ Department of Pediatric Intensive Care Unit, Hangzhou Children's Hospital, Hangzhou, China.
⁴ Department of Pediatric Surgery, Hangzhou Children's Hospital, Hangzhou, 310005, Zhejiang, China. hzchwc123@163.com.

^# Contributed equally.

PMID: 38653853
DOI: 10.1007/s11255-024-04063-z

Abstract

Purpose: Adrenocortical carcinoma (ACC) is an uncommon adrenal gland endocrine tumor that has a poor prognosis in children. We aimed to conduct a population-based cohort study to predict overall survival (OS) in pediatric patients with ACC.

Methods: We used the Surveillance, Epidemiology, and End Results (SEER) database to conduct a retrospective cohort research on pediatric patients diagnosed with ACC between 1975 and 2018. We examined demographic characteristics, tumor stage and size, treatment options, and survival results. Kaplane-Meier estimations were used to generate survival curves based on several parameters. To compare survival curves, the log-rank test was applied.Cox proportional-hazards regression was used to determine the variables related with OS. In addition, we created a nomogram to predict overall survival in pediatric ACC patients.

Results: A total of 143 pediatric ACC patients were identified. Females were the most impacted (60.8%). Overall 1 year, 3 year, and 5 year survival rates were 75.0%, 57.6%, and 53.7% for all patients, respectively. In comparison to older patients (5-19 years), younger patients (≤ 4 years) were shown to have more positive characteristics, including a higher likelihood of local disease (29.4% vs. 14%, P < 0.001), tumors less than 10 cm (23.1% vs. 14.7%, P < 0.001), and improved overall survival (5 year OS 89.6% vs. 27.7%, P < 0.001). Age at diagnosis, SEER stage, and surgery were significant independent predictors of OS in this model, according to the results of Cox proportional hazard regression. After that, we developed a nomogram for predicting OS in children with ACC. Patients older than 4 years old had a higher chance of dying. Furthermore, the higher the SEER stage, the higher the risk of death. Patients who do not have surgery have a worse survival rate than those who do.

Conclusions: Our study revealed that age at diagnosis, SEER stage, and surgery were found to be the most important predictors of the overall survival of pediatric ACC. These findings contribute to the existing body of knowledge and emphasize the importance of continued research to advance our understanding of pediatric ACC and improve patient care.

Keywords: Adrenocortical carcinoma; Age; Pediatric; Seer; Survival.