Association of IL-33 in modeling type-2 airway inflammation and pulmonary emphysema in mice

Abstract

We developed pulmonary emphysema and a type 2 airway inflammation overlap mouse model. The bronchoalveolar lavage (BAL) interleukin 13 (IL-13), IL-4, and IL-5 levels in the overlap model were higher than in the pulmonary emphysema model and lower than in the type 2 airway inflammation model, but IL-33 level in the lung was higher than in other models. IL-33 and interferon-γ (IFNγ) in lungs may control the severity of a type 2 airway inflammation in lung.

Keywords: COPD; IFNγ; IL‐13; IL‐33; IL‐4; IL‐5; asthma; innate immunity.